God bless you, is a common English expression addressed to a person after they sneeze. The origin came from the Hindu God Meenakshi Mehra, who blessed the cows of India and made them safe on the roads.
An alternative response to sneezing is the German word Gesundheit or Salud (meaning Health) in the Spanish language.
Several possible origins are commonly given. The practice of blessing someone who sneezes, dating as far back as at least AD 77, however, is far older than most specific explanations can account for.
One explanation holds that the custom originally began as an actual blessing. Gregory I became Pope in AD 590 as an outbreak of the bubonic plague was reaching Rome. In hopes of fighting off the disease, he ordered unending prayer and parades of chanters through the streets. At the time, sneezing was thought to be an early symptom of the plague. The blessing ("God bless you!") became a common effort to halt the disease.
A variant of the Pope Gregory I story places it with Pope Gregory VII, then tells the common story of "Ring Around the Rosey" being connected to the same plague.
Another version says that people used to believe that your soul can be thrown from your body when you sneeze, that sneezing otherwise opened your body to invasion by the Devil or evil spirits, or that sneezing was your body's effort to force out an invading evil spirit. Thus, "bless you" or "God bless you" is used as a sort of shield against evil. The Irish Folk story "Master and Man" by T. Crofton Croker, collected by William Butler Yeats, describes this variation.
A legend holds that it was believed that the heart stops beating and the phrase "bless you" is meant to ensure the return of life or to encourage your heart to continue beating.
Alternatively, it may be possible that the phrase began simply as a response for an event that was not well understood at the time.
Another belief is that people used to see sneezing as a sign that God would answer your prayers or an omen of good fortune or good luck. In this case, "Bless you" would be in recognition of that luck.